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How Does Tresiba Insulin Work

Who Should Not Take Fiasp

How Tresiba® (insulin degludec injection) 100 U/mL, 200 U/mL Works With Dr. Gavin

Do not take Fiasp® if:

  • your blood sugar is too low or you are allergic to any of its ingredients.

Before taking Fiasp® tell your health care provider about all your medical conditions including, if you:

  • have kidney or liver problems
  • are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if Fiasp® passes into your breast milk.
  • are taking new prescription or over-the-counter medicines, including supplements.

Talk to your health care provider about low blood sugar and how to manage it.

Tresiba Use With Other Drugs

Youll likely use Tresiba with other drugs to help manage your blood sugar levels.

If you have type 1 diabetes, youll typically take Tresiba with a short-acting or rapid-acting insulin. These types of insulin are taken at mealtimes to manage spikes in blood sugar after eating.

Examples of these drugs include:

  • insulin regular human
  • insulin glulisine

If you have type 2 diabetes, youll likely take Tresiba along with diabetes medications that you take by mouth. Examples of these include:

Tresiba is used to treat type 1 and type 2 diabetes in adults and in children ages 1 year and older.

How Should I Use Tresiba

Use Tresiba exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tresiba is injected under the skin, usually once daily at any time of day. A healthcare provider will teach you how to properly use the medication by yourself.

Tresiba must not be given with an insulin pump, or mixed with other insulins. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don’t understand all instructions.

A dose counter on the injection pen shows your dose in units. Do not convert your dose. Use the U-100 vial for a child whose dose is less than 5 units per day.

Do not inject Tresiba into skin that is damaged, tender, bruised, pitted, thickened, scaly, or has a scar or hard lump.

Never share an injection pen with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.

You may have low blood sugar and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar . Be sure you know how to use a glucagon injection kit if your doctor prescribes one.

Also watch for signs of high blood sugar such as increased thirst or urination.

Storing unopened Tresiba:

  • Refrigerate and use until expiration date or

  • Store at room temperature and use within 8 weeks .

Recommended Reading: Medicare Requirements For Continuous Glucose Monitoring

Is Tresiba Used For Diabetes

Tresiba is used to manage blood sugar levels in people with type 1 or type 2 diabetes. Its prescribed for use in children ages 1 year and older and in adults. With type 1 diabetes, your body doesnt make insulin. With type 2 diabetes, your body doesnt make enough insulin to control your blood sugar levels. Tresiba treats type 1 and type 2 diabetes by working like natural insulin. Once you inject Tresiba, the insulin is absorbed into your blood and works to control your sugar levels.

Tresiba may be used with other diabetes medications. It may be combined with short-acting insulin for type 1 diabetes and with oral medication for type 2. If you have questions about your treatment plan for managing diabetes, talk with your doctor.

Whats The Dosage Of Tresiba For Children

How Tresiba® Works

Tresiba is used to treat type 1 and type 2 diabetes in children ages 1 year and older. Your childs starting dosage of Tresiba will depend on whether theyre already using other forms of insulin. Their doctor will continue to adjust their dosage as needed until their blood sugar levels are within a healthy range.

Below is a dosage chart for when Tresiba is prescribed for children.

Recommended starting dose
once per day, at the same time each day
if the child is already using insulin 80% of the total amount of intermediate-acting or long-acting insulin the child has been using each day once per day, at the same time each day

* For example, if your childs doctor prescribes a total daily insulin dose of 20 units, their Tresiba dosage will be 7 units to 10 units each day.

Also Check: Diabetic Food List Type 2

Factors For Deciding The Best Time To Take Tresiba

Tresiba has interactions with certain other medications. So, its important that you discuss with your doctor the timings you should take Tresiba while on other medications or if you can use other medications while on Tresiba.

However, if you take any other medications or supplements in addition to Tresiba, its recommended that you allow a few hours apart before taking Tresiba.

If youre consuming alcohol, your insulin needs might also change. Your blood sugar level may either rise or fall.

Therefore, you should monitor your blood sugar level accurately and more often than usual if you choose to consume alcohol and then decide on a time when you should take Tresiba.

Are The Dosages The Same For Tresiba And Lantus

Tresiba and Lantus have some similarities, but their dosages may be different.

Both Tresiba and Lantus are long-acting insulins used to manage blood sugar levels in people with type 1 or type 2 diabetes. Tresiba contains the active drug insulin degludec, and Lantus contains the active drug insulin glargine.

Both drugs are typically injected under the skin once daily. But Tresibas effects can last for at least 42 hours, while Lantus works for up to 24 hours. For this reason, the exact dosage for each drug may be different.

For more information on how Tresiba and Lantus are alike and different, see this comparison article.

Recommended Reading: Why Can’t Diabetics Donate Plasma

How Should I Take Tresiba

  • Read the Instructions for Use and take Tresiba® exactly as your health care provider tells you to
  • Do not do any conversion of your dose. The dose counter always shows the selected dose in units
  • Know the type and strength of insulin you take. Do not change the type of insulin you take unless your health care provider tells you to
  • Adults – If you miss or are delayed in taking your dose of Tresiba®:
  • Take your dose as soon as you remember, then continue with your regular dosing schedule
  • Make sure there are at least 8 hours between doses
  • If children miss a dose of Tresiba®:
  • For children who need less than 5 units of Tresiba® each day, use a Tresiba® U-100 vial
  • Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them
  • Do not reuse or share your needles or syringes with other people. You may give them a serious infection, or get a serious infection from them
  • Never inject Tresiba® into a vein or muscle
  • Never use a syringe to remove Tresiba® from the FlexTouch® pen
  • Tresiba® can be injected under the skin of your upper legs , upper arms, or stomach area .
  • Change your injection sites within the area you choose with each injection to reduce your risk of getting lipodystrophy and localized cutaneous amyloidosis at the injection sites.
  • Do not use the exact same spot for each injection.
  • Do not inject where the skin has pits, is thickened, or has lumps.
  • Will Tresiba Cure My Diabetes

    Tresiba® (insulin degludec injection) 100 U/mL, 200 U/mL Duration of Action With Dr. Gavin

    No. There is currently no cure for diabetes that needs treatment with insulin. Thats because if your pancreas has stopped producing insulin or cant make enough insulin, theres currently no way to make it work again. Therefore, youll need to continue taking insulin.

    Although there is no cure, insulin drugs like Tresiba can help you manage your diabetes and keep your blood sugar levels under control.

    Recommended Reading: Glucose Test 1 Hour Normal Range

    What Happens If You Take Two Doses Of Tresiba

    If you end up mistakenly taking two doses of Tresiba in the same day, dont panic. Tresiba can take several hours to start working.

    And due to how Tresiba works, it may only have mild negative effects, depending on how close together you took your doses and how many units were administered.

    The recommended advice is to call your doctor and describe your scenario. They will provide you with the most accurate advice depending on your situation.

    Typically, if you take more than one dose of Tresiba in a 24-hour period, you should closely monitor your blood sugar levels.

    Low blood sugar can be very serious and life-threatening.

    Therefore, keep fast-acting carbohydrates with you throughout the day in case you start to feel symptoms of a low. Symptoms may include:

    • Increased appetite

    Tresiba And Other Medications

    Below is a list of medications that can interact with Tresiba. This list does not contain all drugs that may interact with Tresiba.

    Before taking Tresiba, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

    If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

    Tresiba and diabetes drugs called thiazolidinediones

    Taking Tresiba with a type of diabetes drug called a thiazolidinedione can cause heart failure. If you already have heart failure, taking the two drugs together can worsen your condition.

    Examples of thiazolidinedione drugs include rosiglitazone and pioglitazone .

    If you take Tresiba with a thiazolidinedione, tell your doctor right away if you get any new or worsening symptoms of heart failure. These can include:

    • shortness of breath
    • swollen legs, ankles, or feet
    • sudden weight gain

    Tresiba and certain other diabetes drugs

    Taking Tresiba with certain other diabetes medications can raise your risk for hypoglycemia . Examples of these drugs include:

    If you take Tresiba with another diabetes drug, your doctor may adjust your dosage of one or both drugs. This will help reduce your risk for low blood sugar. Your doctor may also ask you to monitor your blood sugar levels more often than you typically would.

    Recommended Reading: High Blood Pressure And High Blood Sugar

    How Is Tresiba Administered

    Tresiba is available only in the FlexTouch pre-filled insulin pen injection device.

    These pens can be stored in the refrigerator until their expiration date. They can also be stored at room temperature for up to 56 days . Once a pen has been opened, it should not be re-refrigerated and should be disposed of after eight weeks.

    Tresiba must be injected under the skin, usually once daily. Be sure you understand how to properly administer an injection so that you dont damage the tissue.

    Do not inject Tresiba if it is cloudy or colored it should be clear.

    Drug Forms And Strengths

    Pin on HEALTH

    Tresiba is taken by subcutaneous injection . Its injected into the thigh, abdomen , or upper arm.

    Tresiba comes as a prefilled injection pen thats available in two strengths. It also comes as a liquid solution thats available in one strength:

    • Tresiba FlexTouch disposable prefilled pen . This pen contains 3 milliliters of drug solution, so it contains a total of 300 units of insulin degludec. It can deliver up to 80 units of insulin degludec with one injection.
    • Tresiba FlexTouch disposable prefilled pen . This pen contains 3 mL of drug solution, so it contains a total of 600 units of insulin degludec. It can deliver up to 160 units of insulin degludec with one injection.
    • Tresiba multidose vial . The vial contains 10 mL of drug solution, so it contains a total of 1,000 units of insulin degludec. You should use a U-100 insulin syringe to measure a dose of Tresiba from the vial.

    Read Also: Does Diabetes Make You Feel Hungry All The Time

    Can Tresiba Be Used To Treat Diabetic Ketoacidosis

    No, its not recommended for this. Diabetic ketoacidosis is a medical emergency thats caused by very high blood sugar levels. DKA usually needs to be treated in a hospital, where insulin is given intravenously until your blood sugar falls to a safe level.

    Tresiba should not be injected into your vein. And when given subcutaneously , it doesnt lower blood sugar quickly enough to treat DKA.

    How Is Tresiba Made

    Tresiba is made using genetic engineering technology.

    Although it resembles human insulin in most of its structure, the amino acid threonine in position B30 has been replaced by a side chain containing glutamine and a C16 fatty acid.

    Tresiba exists as stable insulin dihexamers bonded by zinc. Once Tresiba is injected, the insulin dihexamers form multihexamers. The rate of insulin absorption depends on the size of the insulin molecules, so these large insulin hexamers stay in place, creating an insulin depot .

    With time the zinc diffuses, which releases insulin monomers from each end of the chain. These monomers are the correct size for absorption into the bloodstream.

    Because of the slow and steady way Tresiba breaks up and diffuses under the skin, it lasts for at least 42 hours. This means Tresiba can be dosed once a day, at any time of the day.

    If you miss a dose of Tresiba, it should be injected as soon as you remember. However, if it is less than eight hours before your next dose, just skip that dose and go back to your regular dosing schedule.

    Modifying the structure of human insulin in this way has ensured Tresiba has a slow and consistent rate of absorption into the circulation.

    The primary activity of insulin, including Tresiba, is to allow cells throughout the body to uptake glucose and convert it into a form that can be used by these cells for energy.

    Also Check: Random Blood Sugar Level Chart

    What Does Insulin Do

    Insulin is a hormone that helps cells in your body absorb sugar from your blood. Sugar gets into your blood every time you eat, and its also constantly released into your blood by your liver.

    Insulin stops your blood sugar level from getting too high. It controls your blood sugar levels by:

    • helping cells in your body absorb sugar from your bloodstream, so they can use the sugar for energy
    • helping your muscles use sugar for energy
    • preventing your liver from making and releasing more sugar into your bloodstream
    • helping your body make proteins and store sugar as fat

    The higher the level of sugar in your blood, the more insulin your pancreas releases. If your body cant make enough insulin, your blood sugar levels get too high. High blood sugar can damage cells in your body, especially in your eyes, kidneys, and nerves. Insulin helps keep your blood sugar at safe, normal levels.

    For people with type 1 diabetes and some people with type 2 diabetes, insulin is a vital medication.

    How To Use Tresiba

    Why I Prescribe Tresiba® (insulin degludec injection) 100 U/mL, 200 U/mL For My Patients

    Tresiba is available as a single patient use FlexTouch pen at two different strengths and as multiple dose vials.

    Tresiba is injected under the skin and should be used only once a day at any time of the day. Your health provider will provide specific instructions on how to safely make the injection and any other details you need to know about how to take Tresiba with other medications you are taking for diabetes.

    The usual initial adult dose for type 2 diabetes is 10 subcutaneous units a day. This may be adjusted as the treatment continues.

    For type 1 diabetes, Tresiba should be used in a regimen that also contains short or rapid-acting insulin. The usual initial dose for type 1 diabetes is half or one-third of the total daily insulin requirement per day.

    The injection pen used for Tresiba should never be shared with anyone else and Tresiba should not be used in an insulin pump. Pay attention to any symptoms of hypoglycemia that might occur while you are using Tresiba.

    Also Check: Exercise For Pancreas To Produce Insulin

    Use In Specific Populations

    • Pregnancy: Available data from published studies and postmarketing case reports with Levemir® use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
    • Clinical Considerations Disease-Associated Maternal and/or Embryo/Fetal Risk: Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, and delivery complications. Poorly controlled diabetes increases the fetal risk for major birth defects, stillbirth, and macrosomia-related morbidity.

    Please for Levemir® Prescribing Information.

    Dosage For Type 1 Diabetes

    Recommended dosages of Tresiba for type 1 diabetes are described in the following dosage chart:

    Recommended dose of Tresiba How often its taken
    For adults and children ages 1 year and older not already using insulin: Your doctor will calculate your total daily insulin dose based on your body weight. Your starting dose of Tresiba will be one-half to one-third of your total daily insulin dosage. Once each day.
    For adults already using insulin: Your starting dose of Tresiba will usually be the same as the total unit dose of intermediate or long-acting insulin that youre already using. Once each day.
    For children already using insulin: Your starting dose of Tresiba will be about 80% of the total unit dose of intermediate or long-acting insulin that youre already using. Once each day.

    Its important to note that adults can take Tresiba at any time each day, but children should always stick to the same time. And the rest of your total daily insulin dosage will typically be taken using a short-acting insulin that you inject at mealtimes.

    Also Check: High Level Of Sugar In The Blood:

    Tresiba For Type 2 Diabetes

    Tresiba is also FDA-approved to help manage blood sugar levels in adults and in children ages 1 year and older with type 2 diabetes.

    With type 2 diabetes, cells in your body become resistant to the effects of insulin. This means they dont absorb glucose from your blood as well as they should. As a result, your blood sugar levels can start to get too high. Over time, your pancreas can also stop producing insulin. If that happens, you need to take insulin to help manage your blood sugar.

    Tresiba is a long-acting insulin. It works steadily for up to 42 hours to help keep blood sugar levels under control. Its typically used along with other medications for type 2 diabetes that you take by mouth.

    Effectiveness for type 2 diabetes

    Tresiba has been found to be effective for improving blood sugar management in adults with type 2 diabetes.

    Your blood sugar management is usually assessed using blood tests that measure hemoglobin A1c in your blood. This measurement shows your average blood sugar levels over the past 2 to 3 months. The American Diabetes Association recommends an HbA1c goal of less than 7% for most adults.

    In clinical studies of adults with type 2 diabetes, the effect of Tresiba on HbA1c was compared with insulin glargine and sitagliptin . Insulin glargine is a long-acting insulin, and sitagliptin is a medication for type 2 diabetes thats taken by mouth.

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